When I was of the age to do tough hunts like mule deer I used a 30 06, 265gr hornady spire points. In fact that was the round I used for all my hunting except small game.
I shot my muley last month with the 7 sprc and 175gr Eldx @ 400 yards and he never took a step. My buddy that was with me shot his with a .300 win and 180 Barnes TTSX @ 80 yards and he had the same result.
If I were buying a gun specifically to muley hunt with, it would without question be the 7 PRC with 175 eldx for me. If I didn't want to buy a new gun, I would be confident with just about any rifle I own that is .25 cal or bigger.
I've killed more mule deer with my .240 Weatherby w/100gr Partitions or Sierra Game Kings than anything else. Works great. A .257 Weatherby or a 7mag or anything similar to those will be good deer rounds. I like AccuBonds these days.
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