Brain cancer!

[TwoHighways]

Prayers are well and good, but why does nobody dig into the biology of cancer cells? You don’t need a background in science or medicine to appreciate the Warburg effect.

[Pistol]

Prayers are well and good, but why does nobody dig into the biology of cancer cells? You don’t need a background in science or medicine to appreciate the Warburg effect.

For those who don't know about the Warburg Effect -
The Warburg Effect is named after Otto Warburg in 1924 observed that cancer cells metabolize glucose in a manner that is distinct from that of cells in normal tissues.
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.” Aerobic glycolysis is an inefficient way to generate adenosine 5′-triphosphate (ATP), however, and the advantage it confers to cancer cells has been unclear. (Vander Heiden, Matthew Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation NCIB May 2009)

[Mertzon Man]

Continued prayers for Kristen.
God Bless you both.

[TwoHighways]

For those who don't know about the Warburg Effect -
The Warburg Effect is named after Otto Warburg in 1924 observed that cancer cells metabolize glucose in a manner that is distinct from that of cells in normal tissues.
In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed “the Warburg effect.” Aerobic glycolysis is an inefficient way to generate adenosine 5′-triphosphate (ATP), however, and the advantage it confers to cancer cells has been unclear. (Vander Heiden, Matthew Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation NCIB May 2009)

Two theories around this. One is that they can’t due to structural damage to the mitochondria (well, they can, but they create a lot of reactive oxygen species in the process that would push the cell towards apoptosis if they had to use oxidative phosphorylation to create ATP). The other theory is that cancer cells use the less efficient pathway to ATP creation in order to have the substrate on hand to replicate rapidly, essentially using byproducts of glycolysis and Krebs cycle intermediates as building blocks to grow and divide. Glutamine is the other major player in this and is more problematic to tackle, but Seyfried has a push/pulse concept that addresses this.

[IowaHunter]

4 unchanged MRIs is definitely exciting!

How old is Kristen? My friend's dad is a 7 year survivor of GBM. He was dx when he was 57. The younger the dx the better the odds for long term survival.

I pray for loving kindness, grace, courage and strength for you and Kristen. May you have many more years together! May God bless you both.

Kristin is 55 right now. Better odds with younger age but it also hinges on size, morphology and location of the tumor. Kristin’s was big and has the right characteristics for longevity but it’s been doing the opposite of what’s expected most of this journey.

[HotRod Hunter]

Prayers sent up for Kristin

[Rudyl]

Prayers just sent.

[Tbuddyandroby]

Continued prayers for ya'll!!!

[ForEverlast]

Prayers for Kristen and the entire family !

[IowaHunter]

Earlier than expected MRI done this past week due to persistent headaches since January 13.

Fifth straight stable MRI!!! Doc said he was very pleasantly surprised the progression hasn’t been kicking in. There are two spots they’re keeping an eye on but believe it’s due to radiation effect.

Botox will be started shortly because the pain meds aren’t really helping.

Your prayers are felt, helping and greatly appreciated.

[unclefish]

Continued prayers for Kristin. Hope the pain subsides.

Sent from my SAMSUNG-SM-G930A using Tapatalk

[hogslayer78]

Continued prayers this morning and thank you for the update.

[curtintex]

Thanks for the update. That's good news about the progression...or rather lack of. Hopefully the botox will help with the pain. Continued prayers for Kristin, you and the doctors.

[rvd]

Prayers continue

[doghouse]

More prayers sent!