Do yourself a favor and go to the Chef House across in Port Isabel for a lunch. It's a very small place, but it is top-notch cuisine at a great price.
Pelican Station in Port Isabel is owned/operated by the same people as Dirty Al's. Same menu, but might be easier to get into and better service on the holiday week. It's on the water right before you get to the Queen Isabela bridge.
Dirty Al's has awesome fried shrimps and great prices. Blackbeards has great burgers. Louies Backyard has a prety good buffet. All you can eat prime rib and crab legs. They have a nice deck to watch the sunset over the bay. Daddys has good cajun style food for northern Mexico.
Several good ones mentioned. Dirty Als blackened shrimp. Gabriela's is good too. But I can't visit without hitting up the padre island brewery for pizza and their wheat beer.
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